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CHARLESTON, S.C. (AP) — In a story of political redemption, Mark Sanford is headed back to Congress after his career was derailed by scandal four years ago.

"I am one imperfect man saved by God's grace," the Republican told about 100 cheering supporters Tuesday after defeating Democrat Elizabeth Colbert Busch to win back the 1st District seat he held for three terms in the 1990s. "It's my pledge to all of you going forward I'm going to be one of the best congressmen I could have ever been."

On Wednesday, Sanford told NBC's "Today" show he thinks his record as a watchdog for taxpayers was more important than his personal redemption story.

"I think I have an incredibly strong track record with regard to watching out for people's pocketbook," he said.

Although the race was thought to be close going into the voting, Sanford collected 54 percent of the vote against Colbert Busch, the sister of political satirist Stephen Colbert, in a district that hasn't elected a Democratic congressman in more than three decades. About 32 percent of the district's voters went to the polls. Green Party candidate Eugene Platt finished far behind.

"Some guy came up to me the other day and said you look a lot like Lazarus," Sanford told the crowd Tuesday night, referring to the man who, according to the Bible, Christ raised from the dead. "I've talked a lot about grace during the course of this campaign," he said. "Until you experience human grace as a reflection of God's grace, I don't think you really get it. And I didn't get it before."

While he credited his conservative credentials on Wednesday, he did not back away from his problems.

"I let a lot of folks down back in 2009 and yet I've been on a remarkable personal journey since then and I hope my life will reflect that going forward," Sanford said.

Sanford, who turns 53 later this month, has now never lost a race in four runs for Congress and two for governor. And he said before the votes were counted Tuesday that if he lost this one, he wouldn't run for office again.

He saw his political career disintegrate in summer 2009 when he disappeared for five days, telling his staff he was hiking the Appalachian Trail. He returned to admit in a tearful news conference he had been in Argentina with his mistress — a woman to whom he is now engaged. Sanford later paid a $70,000 ethics fine, the largest in state history, for using public money to fly for personal purposes. His wife and political ally, Jenny, divorced him.

Three weeks before the special election, news surfaced that Sanford's ex-wife had filed a court complaint alleging he was in her house without permission in violation of their divorce decree, leading the National Republican Congressional Committee to pull its support from the campaign. Sanford must appear in court Thursday on the complaint.

Sanford said he tried to get in touch with his ex-wife and was in the house so his youngest son would not have to watch the Super Bowl alone.

The congressional seat became vacant when U.S. Sen. Jim DeMint resigned from his Senate seat late last year. Governor Nikki Haley then appointed the sitting congressman, Tim Scott, to fill DeMint's seat.

"We put up a heck of a fight, didn't we?" Colbert Busch told a crowd of supporters at a hotel in Charleston. "The people have spoken, and I respect their decision."

Although the district is strongly Republican, Colbert Busch raised more money than Sanford. And national Democrats flooded the airwaves with ads attacking Sanford's past indiscretions.

Steve Israel, the chairman of the Democratic Congressional Campaign Committee, said Sanford now becomes the face of the Republican efforts to reach out to women voters and the GOP will have to defend him.

"In this deep red Republican district that Mitt Romney won by 18 points, the fact that the Democrat made this competitive is a testament to the strength of Elizabeth Colbert Busch as a candidate and the Republican habit of nominating flawed candidates," he said in a statement.

But Greg Walden, his counterpart at the National Republican Congressional Committee countered that the "results demonstrate just how devastating the policies of Barack Obama and Nancy Pelosi are for House Democrats in 2014. Democrats spent more than $1 million trying to elect a candidate who was backed by the Democrat machine, but at the end of the day, running on the Obama-Pelosi ticket was just too toxic for Elizabeth Colbert Busch."

NEWARK, N.J. (AP) -- Gov. Chris Christie, who once famously called himself "the healthiest fat guy you've ever seen," disclosed Tuesday he had secretly undergone weight-loss surgery, a major new step by the potential Republican presidential contender to address both his health and a political vulnerability.

The stakes are high for Christie, with medical professionals and campaign strategists alike suggesting there is no more serious barrier to his personal well-being and national ambitions than his weight.

It's not about politics, he said. It's about turning 50 and wanting to be around as his children grow up.

"This is a hell of a lot more important to me than running for president," Christie, a father of four, said at a news conference in Newark. "This is about my family's future."

Christie, who appeared thinner than he did earlier this year, said he decided around the time of his birthday in September to have the surgery and initially planned to have it done in November. But Superstorm Sandy's destruction in New Jersey pushed back the procedure until February. In the operation, a band was surgically placed around his stomach to restrict how much food he could eat.

Christie has not previously disclosed his weight, and he didn't on Tuesday. But it has been an issue throughout his political career. Comedians have often made fun of it, and in interviews with David Letterman, Oprah Winfrey, Barbara Walters and others, Christie has both joked about the issue and said solemnly that he was trying to shed pounds.

During a February appearance on "The Late Show with David Letterman," the governor pulled out a doughnut and said his girth was "fair game" for comedians.

Over the next few days, he was asked repeatedly about his weight. At one point, he said he had a plan. "Whether it's successful or not," he said, "you'll all be able to notice."

The next day, he responded angrily to comments from a former White House physician who said she hoped he would run for president but worried about him dying in office. The governor said the doctor should "shut up."

Ten days after that, on Feb. 16, Christie had the surgery. He said the operation lasted 40 minutes and he was home the same afternoon. He was back at work on Feb. 19 for a full day of events.

Christie, who is in the midst of a re-election campaign, said he has been eating less because he hasn't been as hungry. He also has been working out with a personal trainer.

He said he had told only a few top staffers - not his communications office or campaign staff - and his communications director was caught by surprise Monday when a New York Post reporter asked directly if he'd had the procedure. The Post first reported the surgery on Tuesday. Christie said he'd used an alias at the hospital.

Christie said he never intended to make a public announcement and that he was "not going to be the guy who writes a book" about losing weight. The Republican, who has been a fixture in the national media spotlight, said the scrum of reporters at his news conference was "silly" and "ridiculous" at a time when there are other things going on.

He said he tried other ways to lose weight for years, but none seemed to work.

"It's not a career issue for me; it's a long-term health issue for me," he said.

Still, it's a way to confront a significant hurdle in his indisputable quest to emerge as a key leader in the Republican Party. He's in the top tier of those considered potential contenders for the presidential nomination in 2016.

Weeks after the surgery, Christie launched an aggressive national fundraising tour, fueling speculation that he's laying the groundwork for a White House bid.

In a country facing an obesity epidemic, more than 220,000 stomach-reducing procedures of various types are performed each year. Gastric bypass, sometimes called stomach stapling, is the most common, where surgeons shrink the stomach's size and reroute food to the small intestine. Christie had gastric band surgery. It's best known by the brand name Lap-Band, and is a less invasive alternative in which an adjustable ring is placed over the top of the stomach and tightened to restrict how much food can enter.

The adjustable Lap-Band has been available in the U.S. since 2001 for the most obese patients, and in 2011 the Food and Drug Administration expanded approval to somewhat less obese patients.

Candidates for gastric banding must have a body mass index of between 30 and 40 - plus a weight-related medical condition, such as diabetes or high blood pressure - or a BMI of 40 and higher. They also must have previously attempted to lose weight through diet and exercise.

"If you eat appropriately and chew your food, it works nicely," said Dr. Christina Li, a bariatric doctor at Sinai Hospital of Baltimore. She said Christie has the resources to have people help him eat right and get exercise. While the band is removable, she said patients are told to adjust to having it for the rest of their lives.

Li said risks include infection, and that it does not work for all patients.

Dr. Jaime Ponce, who practices in Dalton, Ga., and is president of the American Society for Metabolic & Bariatric Surgery, said people who have the procedure Christie had often lose 1 to 2 pounds per week.

Christie's procedure was performed by Dr. George Fielding, head of NYU Medical Center's Weight Management Program, who did the same procedure for New York Jets coach Rex Ryan three years ago.

"It basically teaches you how to eat like a human," Ryan said of the device in an interview last week with The Associated Press. "The Lap-Band goes: `No, no. You're only going to eat this or that,' and it trains your body how to eat right," said Ryan, who said he has lost 115 pounds from his pre-surgery weight of 348.

Few significantly overweight presidential candidates have succeeded in the modern political era, when television became a major factor in shaping voter attitudes. There are disputed reports that President William Howard Taft couldn't fit in a White House bathtub a century ago, but only a handful of presidents since have been considered obese. President Bill Clinton struggled at times with his weight, but he was substantially slimmer than the New Jersey governor.

"This has nothing to do with politics," said Christie adviser Bill Palatucci. "He said that he's doing this for his family and that's the right reason."

Backers publicly argue that Christie answered any questions about his weight's political impact in 2009, when he beat Gov. Jon Corzine despite the Democrat's reference in an ad to Christie "throwing his weight around" to get out of traffic tickets. Supporters say Christie's openness about his struggle is part of an authenticity people admire in him.

The governor's allies, medical professionals and even history suggest that his weight presents both practical and political problems.

"Gov. Christie's weight is an issue the same way that any candidate or official's health is an issue," said Michael Dennehy, a New Hampshire-based Republican strategist and veteran of presidential politics. "Anyone running for president will need to comfort Americans with an overall healthy picture for their future."

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Mulvihill reported from Haddonfield, N.J., and Peoples from Providence, R.I. AP Medical Writer Lauran Neergaard in Washington, AP writers Thomas Beaumont in Des Moines, Iowa, and AP Sports Writer Dennis Waszak in New York contributed to this report.

© 2013 THE ASSOCIATED PRESS. ALL RIGHTS RESERVED. THIS MATERIAL MAY NOT BE PUBLISHED, BROADCAST, REWRITTEN OR REDISTRIBUTED. Learn more about our PRIVACY POLICY and TERMS OF USE.

DEERFIELD, Ill. (AP) -- Baxter International Inc. says that a blood product it was testing failed to slow mental decline or to preserve physical function in a major study of 390 patients with mild to moderate Alzheimer's disease.

The company says that people who received 18 months of infusions with its drug, Gammagard, fared no better than others given infusions of a dummy solution.

Gammagard is immune globulin, natural antibodies culled from donated blood. Researchers thought these antibodies might help remove amyloid, the sticky plaque that clogs patients' brains, sapping memory and ability to think.

Patients with moderate disease and those with a gene that raises risk of Alzheimer's who were taking the higher of two doses in the study seemed to benefit, although the study was not big enough to say for sure.

"The study missed its primary endpoints, however we remain interested by the prespecified sub-group analyses" in groups that seemed to benefit, Ludwig Hantson, president of Baxter's BioScience business, said in a statement.

Gammagard is already sold to treat some blood disorders, and the results of the Alzheimer's study do not affect those uses. About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.

Excitement about Gammagard grew last summer, when researchers reported at a medical conference that the drug had stabilized Alzheimer's disease for as much as three years in four patients who had been receiving the highest dose of it for three years in the study. People typically go from diagnosis to death in about eight years, so to be stable for so long was considered remarkable.

The new results on the full group of study participants are disappointing, said the study's leader, Dr. Norman Relkin, head of a memory disorders program at New York-Presbyterian Hospital/Weill Cornell Medical Center.

"The bar was set very high" for the drug to show improvement, and "there does appear to be a signal" that it helped the two-thirds of patients in the study who had the apoE4 gene that raises the risk of developing Alzheimer's, as well as those with moderate versus mild disease, Relkin said.

No new side effects were seen in the study. About 5 percent of patients on the drug had a rash and decreases in hemoglobin, which carries oxygen in the blood. There were 17 serious reactions, 12 in the drug group and five in the placebo group.

Full results will be presented in July at an Alzheimer's conference in Boston.

Meanwhile, other studies are under way to test drugs earlier in the course of the disease. An experimental drug, Eli Lilly & Co.'s solanezumab, showed some promise in that setting in an earlier study.

Shares of Baxter fell $2.53, or 3.6 percent, to $67.78 in morning trading.

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Marilynn Marchione can be followed at HTTP://TWITTER.COM/MMARCHIONEAP © 2013 THE ASSOCIATED PRESS. ALL RIGHTS RESERVED. THIS MATERIAL MAY NOT BE PUBLISHED, BROADCAST, REWRITTEN OR REDISTRIBUTED. Learn more about our PRIVACY POLICY and TERMS OF USE.