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A gunman wearing an Afghan police uniform opened fire at a police training facility in eastern Afghanistan today, killing at least two American troops and three Afghans, officials say.

The shooting took place while the troops were visiting the facility to help train the Afghans, a key part of the U.S. handover strategy before combat troops leave in 2014. According to coalition officials, the shooting also left several wounded.

A joint U.S.-Afghan team is investigating the shooting.

This latest insider attack in Wardak, a restive province in the country's east, comes one day after a deadline set by Afghan President Hamid Karzai for all U.S. Special Forces to leave the province. Karzai set the deadline two weeks ago, after accusing Afghans who work for U.S. Special Forces of harassing, torturing and murdering innocent civilians.

The attack also comes just a day after new U.S. Secretary of Defense Chuck Hagel's trip to Afghanistan, one marred by controversy.

Osama bin Laden's Son-in-Law Pleads Not Guilty in NYC Court Watch Video On Saturday, a suicide bomber on a bicycle struck just outside the Afghan Ministry of Defense, one of the most heavily fortified buildings in the country. At least nine Afghan civilians were killed. Though Hagel was in a meeting at a coalition military base at the time and never in any danger, nearby bases were put into lockdown, and reporters travelling with Hagel's press pool were ushered into a safe room in the basement of the base they were on.

Then on Sunday, Karzai implied the Taliban were serving U.S. interests by creating instability in Afghanistan. The inflammatory comments were made during a nationally televised speech.

Referring to recent insurgent attacks, including the one outside the Ministry of Defense, Karzai said the attacks were "not aimed at showing their strength to the USA, but to serve the USA.

"In fact, yesterday's bombings in the name of the Taliban were aimed at serving the foreigners and supporting the presence of the foreigners in Afghanistan and keeping them in Afghanistan, by intimidating us," Karzai said.

The top U.S. commander in Afghanistan, Gen. Joseph Dunford, quickly rejected the comments, calling them "categorically false."

"We have fought too hard over the past 12 years, we have shed too much blood over the last 12 years, to ever think that violence or instability would be to our advantage," Dunford said.

Later that evening, Hagel cancelled a scheduled joint press conference with Karzai. A spokesperson cited security concerns, though a Karzai spokesperson said it was due to "scheduling pressures." The two still held a private dinner meeting with Dunford in attendance, but the cancellation of the joint press conference was widely seen as a snub to Karzai in response to his inflammatory remarks.